Brain Development in Schizophrenia and Autism


Clancy D. McKenze, M.D.

Dear David Icke,

Paul MacLean concurred with my findings of where and how the schizophrenic process was taking place in the brain, and the findings have been confirmed with data on 9,000 persons with the disorder

Autism might relate to a similar process. Both involve activation of phylogenetically earlier developmental brain structures to the partial exclusion of later developmental ones.

I have identified unsuspected infant separation traumas in the first two years of life that correlate with the later development of schizophrenia. The identical traumas in the next year of life correlate with the later development of non psychotic major depression.

The mechanism is delayed posttraumatic stress disorder from infancy, and it is reactivated later in life by a similar separation from some other "most important person" (husband, wife, girlfriend, boyfriend -- or group). The flashback is a partial shift to the entire earlier gestalt, the earlier mind/brain/reality/ feelings/behavior/ chemistry/ physiology and neuroanatomic sites active and developing at the precise time of the earlier trauma during infancy.

The earlier brain structures produce more of the neurotransmitters involved in the disease process, and when reactivated they produce more. The corresponding deactivation of higher cortical structures results in disuse atrophy. Thus we have an apparent neurodevelopmental disorder -- but which really is a psycho-neurodevelopmental disorder. Sarnoff Mednick confirmed this for me on the 6,000 in the Finnish data base on Schizophrenia, and Mortensen provided data on the 2,700 in the Danish cohort on schizophrenia which was significant beyond .000001.

The gender ratio of 4-7 to 1 in autism causes me to wonder about early traumas in males that do not occur in females. The obvious one is circumcision -- without anesthesia and without the mother present. This occurs at a time when the infant is using reptilian and old mammalian brain. The reptilian brain is active or there would not be the Moro reflex, for example.

(Much of this is described in my textbook or on my web site.)

Early trauma could result in fixation of activity in early developmental regions of brain. These sites could serve as epileptogenic focal points of activity and be caused to perceverate -- to the exclusion of later developmental regions -- such as the language centers in the left posterier superior temporal gyrus -- which would then fail to develop.

I soon will be conducting a study in India, because Muslims and Hindus live side by side in the same culture. Hindus are not circumcised, but for muslims it is law by age three days.


Clancy D. McKenze, M.D.
Chairman, Dept of Behavioral Medicine
Capital University of Integratiive Medicine
Washington DC

Recommended Reading:
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by Jess Miller

A How-To Guide on overcoming fear, stress, anxiety and depression, by one who did.


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